Drug interactions
Cyproheptadine + Metoclopramide
Severity: Moderate
Cyproheptadine and Metoclopramide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cyproheptadine is a sedating antihistamine with anticholinergic and antiserotonergic activity. It may increase drowsiness when combined with metoclopramide and its anticholinergic effects may blunt metoclopramide's gastrointestinal effects.
What this interaction means in plain words
Cyproheptadine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cyproheptadine belongs to Respiratory; Metoclopramide belongs to Gastrointestinal Tract.
Why it happens
Additive central nervous system depression and anticholinergic antagonism of prokinetic action.
What to do
Warn the patient about drowsiness and monitor for reduced antiemetic or prokinetic response. Reduce dose if sedation is excessive.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoclopramide
Other interactions of Cyproheptadine
- Cyproheptadine + Isocarboxazid Contraindicated
- Cyproheptadine + Phenelzine Contraindicated
- Cyproheptadine + Tranylcypromine Contraindicated
- Alfentanil + Cyproheptadine Major
- Belladonna and opium + Cyproheptadine Major
- Benzhydrocodone / acetaminophen + Cyproheptadine Major
Frequently asked questions
Can I take Cyproheptadine with Metoclopramide?
MediHelp rates the interaction as moderate. Cyproheptadine and Metoclopramide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Cyproheptadine is a sedating antihistamine with anticholinergic and antiserotonergic activity. It may increase drowsiness when combined with metoclopramide and its anticholinergic effects may blunt metoclopramide's gastrointestinal effects.
How serious is the interaction between Cyproheptadine and Metoclopramide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Warn the patient about drowsiness and monitor for reduced antiemetic or prokinetic response. Reduce dose if sedation is excessive.
What other medicines interact with Metoclopramide?
MediHelp also lists interactions of Metoclopramide with, for example, Amantadine, Amoxapine, Antipsychotics (e.g., haloperidol). The full list is on the Metoclopramide page.
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