Drug interactions
Dabigatran etexilate + Nintedanib
Severity: Moderate
Dabigatran etexilate and Nintedanib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Nintedanib inhibits VEGF receptors and is associated with an increased bleeding tendency, which may add to the risk with full-dose dabigatran. Nintedanib is also a P-glycoprotein substrate.
What this interaction means in plain words
Dabigatran etexilate and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Nintedanib belongs to Oncology.
Why it happens
Additive bleeding risk from VEGFR inhibition combined with thrombin inhibition.
What to do
Use only if benefit outweighs risk and monitor closely for bleeding. Adjust or interrupt therapy if bleeding occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Nintedanib
- Amiodarone + Nintedanib Moderate
- Apixaban + Nintedanib Moderate
- Argatroban + Nintedanib Moderate
- Azithromycin + Nintedanib Moderate
- Carbamazepine + Nintedanib Moderate
- Carvedilol + Nintedanib Moderate
Frequently asked questions
Can I take Dabigatran etexilate with Nintedanib?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Nintedanib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Nintedanib inhibits VEGF receptors and is associated with an increased bleeding tendency, which may add to the risk with full-dose dabigatran. Nintedanib is also a P-glycoprotein substrate.
How serious is the interaction between Dabigatran etexilate and Nintedanib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use only if benefit outweighs risk and monitor closely for bleeding. Adjust or interrupt therapy if bleeding occurs.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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