Drug interactions
Dabigatran etexilate + Posaconazole
Severity: Major
Dabigatran etexilate and Posaconazole: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Posaconazole is a P-glycoprotein inhibitor and may increase dabigatran exposure, raising the risk of bleeding. The risk is greater in patients with reduced renal function.
What this interaction means in plain words
Dabigatran etexilate and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabigatran etexilate belongs to Cardiovascular; Posaconazole belongs to Anti Fungals.
Why it happens
Inhibition of intestinal P-glycoprotein efflux of dabigatran etexilate.
What to do
Avoid in patients with reduced creatinine clearance, consistent with dabigatran labeling. Otherwise monitor closely for bleeding and consider an alternative anticoagulant or antifungal.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Posaconazole
- Artemether + Posaconazole Contraindicated
- Avanafil + Posaconazole Contraindicated
- Cobimetinib + Posaconazole Contraindicated
- Conivaptan + Posaconazole Contraindicated
- Dihydroergotamine intranasal + Posaconazole Contraindicated
- Dihydroergotamine + Posaconazole Contraindicated
Frequently asked questions
Can I take Dabigatran etexilate with Posaconazole?
MediHelp rates the interaction as major. Dabigatran etexilate and Posaconazole can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Posaconazole is a P-glycoprotein inhibitor and may increase dabigatran exposure, raising the risk of bleeding. The risk is greater in patients with reduced renal function.
How serious is the interaction between Dabigatran etexilate and Posaconazole?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid in patients with reduced creatinine clearance, consistent with dabigatran labeling. Otherwise monitor closely for bleeding and consider an alternative anticoagulant or antifungal.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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