Drug interactions
Dabigatran etexilate + Sodium zirconium cyclosilicate
Severity: Minor
Dabigatran etexilate and Sodium zirconium cyclosilicate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium zirconium cyclosilicate can transiently raise gastric pH, and dabigatran capsules absorb best in acidic conditions, so exposure could fall. Labeling for the potassium binder advises separating it from drugs with pH-dependent absorption.
What this interaction means in plain words
Dabigatran etexilate and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabigatran etexilate belongs to Cardiovascular; Sodium zirconium cyclosilicate belongs to Miscellaneous.
Why it happens
Increased gastric pH may reduce dissolution and absorption of dabigatran etexilate.
What to do
Give dabigatran at least 2 hours before or after sodium zirconium cyclosilicate.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Sodium zirconium cyclosilicate
- Cefditoren + Sodium zirconium cyclosilicate Moderate
- Cefpodoxime + Sodium zirconium cyclosilicate Moderate
- Cefuroxime + Sodium zirconium cyclosilicate Moderate
- Crizotinib + Sodium zirconium cyclosilicate Moderate
- Dasatinib + Sodium zirconium cyclosilicate Moderate
- Erlotinib + Sodium zirconium cyclosilicate Moderate
Frequently asked questions
Can I take Dabigatran etexilate with Sodium zirconium cyclosilicate?
MediHelp rates the interaction as minor. Dabigatran etexilate and Sodium zirconium cyclosilicate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Sodium zirconium cyclosilicate can transiently raise gastric pH, and dabigatran capsules absorb best in acidic conditions, so exposure could fall. Labeling for the potassium binder advises separating it from drugs with pH-dependent absorption.
How serious is the interaction between Dabigatran etexilate and Sodium zirconium cyclosilicate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give dabigatran at least 2 hours before or after sodium zirconium cyclosilicate.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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