Drug interactions
Dabigatran etexilate + Tepotinib
Severity: Moderate
Dabigatran etexilate and Tepotinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tepotinib inhibits P-gp and increased exposure to the P-gp substrate dabigatran in clinical study. Higher dabigatran levels may raise bleeding risk.
What this interaction means in plain words
Dabigatran etexilate and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabigatran etexilate belongs to Cardiovascular; Tepotinib belongs to Oncology.
Why it happens
Inhibition of intestinal P-glycoprotein by tepotinib increases dabigatran absorption.
What to do
Monitor for bleeding signs and renal function during coadministration. Consider a dabigatran dose reduction per labeling or an alternative anticoagulant if bleeding risk is high.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Tepotinib
- Colchicine + Tepotinib Major
- Digoxin + Tepotinib Major
- Tepotinib + Vincristine Major
- Amiodarone + Tepotinib Moderate
- Apixaban + Tepotinib Moderate
- Atorvastatin + Tepotinib Moderate
Frequently asked questions
Can I take Dabigatran etexilate with Tepotinib?
MediHelp rates the interaction as moderate. Dabigatran etexilate and Tepotinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Tepotinib inhibits P-gp and increased exposure to the P-gp substrate dabigatran in clinical study. Higher dabigatran levels may raise bleeding risk.
How serious is the interaction between Dabigatran etexilate and Tepotinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding signs and renal function during coadministration. Consider a dabigatran dose reduction per labeling or an alternative anticoagulant if bleeding risk is high.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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