Drug interactions
Dabigatran etexilate + Ticlopidine
Severity: Major
Dabigatran etexilate and Ticlopidine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ticlopidine inhibits platelet aggregation and, combined with dabigatran, raises the risk of significant bleeding. Ticlopidine also carries hematologic toxicity risks that complicate monitoring.
What this interaction means in plain words
Dabigatran etexilate and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dabigatran etexilate belongs to Cardiovascular; Ticlopidine belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic effect: thrombin inhibition by dabigatran and P2Y12 platelet inhibition by ticlopidine.
What to do
Avoid unless a clear indication exists; clopidogrel or another agent is usually preferred. If used, monitor closely for bleeding and blood counts.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dabigatran etexilate
- Dabigatran etexilate + Defibrotide Contraindicated
- Dabigatran etexilate + Ketorolac Contraindicated
- Dabigatran etexilate + Mifepristone Contraindicated
- Abciximab + Dabigatran etexilate Major
- Alteplase + Dabigatran etexilate Major
- Amiodarone + Dabigatran etexilate Major
Other interactions of Ticlopidine
Frequently asked questions
Can I take Dabigatran etexilate with Ticlopidine?
MediHelp rates the interaction as major. Dabigatran etexilate and Ticlopidine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Ticlopidine inhibits platelet aggregation and, combined with dabigatran, raises the risk of significant bleeding. Ticlopidine also carries hematologic toxicity risks that complicate monitoring.
How serious is the interaction between Dabigatran etexilate and Ticlopidine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid unless a clear indication exists; clopidogrel or another agent is usually preferred. If used, monitor closely for bleeding and blood counts.
What other medicines interact with Dabigatran etexilate?
MediHelp also lists interactions of Dabigatran etexilate with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dabigatran etexilate page.
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