Drug interactions
Dabrafenib + Fenofibrate
Severity: Minor
Dabrafenib and Fenofibrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and other enzymes and may lower exposure to substrates. Fenofibrate depends little on CYP3A4, so any reduction in effect is likely small.
What this interaction means in plain words
Dabrafenib and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dabrafenib belongs to Oncology; Fenofibrate belongs to Cardiovascular.
Why it happens
Dabrafenib induces CYP3A4 and possibly UGT enzymes, which could modestly speed up clearance of fenofibric acid.
What to do
No empiric dose change is needed. Check the lipid profile if the response is reduced.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Fenofibrate?
MediHelp rates the interaction as minor. Dabrafenib and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dabrafenib induces CYP3A4 and other enzymes and may lower exposure to substrates. Fenofibrate depends little on CYP3A4, so any reduction in effect is likely small.
How serious is the interaction between Dabrafenib and Fenofibrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empiric dose change is needed. Check the lipid profile if the response is reduced.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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