Drug interactions
Dabrafenib + Rolapitant
Severity: Moderate
Dabrafenib and Rolapitant: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dabrafenib induces CYP3A4 and may lower rolapitant exposure. Reduced antiemetic efficacy could occur.
What this interaction means in plain words
Dabrafenib and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dabrafenib belongs to Oncology; Rolapitant belongs to Gastrointestinal Tract.
Why it happens
Dabrafenib induces CYP3A4, accelerating rolapitant metabolism.
What to do
Monitor for breakthrough nausea and vomiting, and consider an alternative antiemetic if control is inadequate.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Other interactions of Dabrafenib
Frequently asked questions
Can I take Dabrafenib with Rolapitant?
MediHelp rates the interaction as moderate. Dabrafenib and Rolapitant can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dabrafenib induces CYP3A4 and may lower rolapitant exposure. Reduced antiemetic efficacy could occur.
How serious is the interaction between Dabrafenib and Rolapitant?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for breakthrough nausea and vomiting, and consider an alternative antiemetic if control is inadequate.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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