Drug interactions
Dacarbazine + Givosiran
Severity: Moderate
Dacarbazine and Givosiran: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Givosiran can reduce CYP1A2 activity, and dacarbazine is activated and cleared partly through CYP1A2. Altered exposure to dacarbazine could change its efficacy or toxicity, although the clinical effect has not been well characterized.
What this interaction means in plain words
Dacarbazine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacarbazine belongs to Oncology; Givosiran belongs to Miscellaneous.
Why it happens
Givosiran-related inhibition of CYP1A2 may alter dacarbazine metabolism.
What to do
Monitor for dacarbazine toxicity, especially myelosuppression and nausea, and consider alternatives if a sensitive CYP1A2 effect is a concern.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dacarbazine
Other interactions of Givosiran
- Duloxetine + Givosiran Major
- Givosiran + Pimozide Major
- Givosiran + Propafenone Major
- Givosiran + Theophylline Major
- Givosiran + Thioridazine Major
- Givosiran + Tizanidine Major
Frequently asked questions
Can I take Dacarbazine with Givosiran?
MediHelp rates the interaction as moderate. Dacarbazine and Givosiran can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Givosiran can reduce CYP1A2 activity, and dacarbazine is activated and cleared partly through CYP1A2. Altered exposure to dacarbazine could change its efficacy or toxicity, although the clinical effect has not been well characterized.
How serious is the interaction between Dacarbazine and Givosiran?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dacarbazine toxicity, especially myelosuppression and nausea, and consider alternatives if a sensitive CYP1A2 effect is a concern.
What other medicines interact with Dacarbazine?
MediHelp also lists interactions of Dacarbazine with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Dacarbazine page.
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