Drug interactions
Dacomitinib + Fluphenazine
Severity: Moderate
Dacomitinib and Fluphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6, which is a main pathway for fluphenazine clearance. Fluphenazine exposure may rise, increasing sedation, extrapyramidal effects and QT-related risk.
What this interaction means in plain words
Dacomitinib and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacomitinib belongs to Oncology; Fluphenazine belongs to Central Nervous System.
Why it happens
Dacomitinib inhibits CYP2D6, reducing fluphenazine metabolism.
What to do
Monitor for extrapyramidal symptoms, sedation and hypotension, and consider reducing the fluphenazine dose or choosing an antipsychotic not dependent on CYP2D6.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Fluphenazine
- Arsenic trioxide + Fluphenazine Contraindicated
- Dofetilide + Fluphenazine Contraindicated
- Fluphenazine + Ibutilide Contraindicated
- Fluphenazine + Pimozide Contraindicated
- Adagrasib + Fluphenazine Major
- Alfentanil + Fluphenazine Major
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Fluphenazine?
MediHelp rates the interaction as moderate. Dacomitinib and Fluphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib strongly inhibits CYP2D6, which is a main pathway for fluphenazine clearance. Fluphenazine exposure may rise, increasing sedation, extrapyramidal effects and QT-related risk.
How serious is the interaction between Dacomitinib and Fluphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for extrapyramidal symptoms, sedation and hypotension, and consider reducing the fluphenazine dose or choosing an antipsychotic not dependent on CYP2D6.
What other medicines interact with Fluphenazine?
MediHelp also lists interactions of Fluphenazine with, for example, Arsenic trioxide, Dofetilide, Ibutilide. The full list is on the Fluphenazine page.
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