Drug interactions
Dacomitinib + Fluvoxamine
Severity: Minor
Dacomitinib and Fluvoxamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6, but fluvoxamine is not a primary CYP2D6 substrate, so the interaction is the reverse of the one suggested. Fluvoxamine is mainly cleared by CYP2D6 and CYP1A2, so dacomitinib may modestly raise fluvoxamine levels without serious toxicity expected.
What this interaction means in plain words
Dacomitinib and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dacomitinib belongs to Oncology; Fluvoxamine belongs to Central Nervous System.
Why it happens
Dacomitinib CYP2D6 inhibition may modestly raise fluvoxamine exposure.
What to do
No routine change is needed. Monitor for fluvoxamine adverse effects such as nausea and sedation.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fluvoxamine
- Agomelatine + Fluvoxamine Contraindicated
- Alosetron + Fluvoxamine Contraindicated
- Fezolinetant + Fluvoxamine Contraindicated
- Fluvoxamine + Isocarboxazid Contraindicated
- Fluvoxamine + Mavacamten Contraindicated
- Fluvoxamine + Methylene blue Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Fluvoxamine?
MediHelp rates the interaction as minor. Dacomitinib and Fluvoxamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dacomitinib strongly inhibits CYP2D6, but fluvoxamine is not a primary CYP2D6 substrate, so the interaction is the reverse of the one suggested. Fluvoxamine is mainly cleared by CYP2D6 and CYP1A2, so dacomitinib may modestly raise fluvoxamine levels without serious toxicity expected.
How serious is the interaction between Dacomitinib and Fluvoxamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed. Monitor for fluvoxamine adverse effects such as nausea and sedation.
What other medicines interact with Fluvoxamine?
MediHelp also lists interactions of Fluvoxamine with, for example, Agomelatine, Alosetron, Fezolinetant. The full list is on the Fluvoxamine page.
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