Drug interactions
Dacomitinib + Haloperidol
Severity: Moderate
Dacomitinib and Haloperidol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6 and can raise haloperidol concentrations, increasing the risk of QT prolongation, sedation and extrapyramidal effects. The effect is clinically relevant because haloperidol is partly cleared via CYP2D6.
What this interaction means in plain words
Dacomitinib and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacomitinib belongs to Oncology; Haloperidol belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated haloperidol metabolism by dacomitinib.
What to do
Monitor for haloperidol toxicity including QTc prolongation and extrapyramidal symptoms, and reduce the haloperidol dose if needed. Consider an antipsychotic not dependent on CYP2D6.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Haloperidol
- Dofetilide + Haloperidol Contraindicated
- Dronedarone + Haloperidol Contraindicated
- Haloperidol + Ibutilide Contraindicated
- Haloperidol + Levoketoconazole Contraindicated
- Haloperidol + Panobinostat Contraindicated
- Haloperidol + Pimozide Contraindicated
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Haloperidol?
MediHelp rates the interaction as moderate. Dacomitinib and Haloperidol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib strongly inhibits CYP2D6 and can raise haloperidol concentrations, increasing the risk of QT prolongation, sedation and extrapyramidal effects. The effect is clinically relevant because haloperidol is partly cleared via CYP2D6.
How serious is the interaction between Dacomitinib and Haloperidol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for haloperidol toxicity including QTc prolongation and extrapyramidal symptoms, and reduce the haloperidol dose if needed. Consider an antipsychotic not dependent on CYP2D6.
What other medicines interact with Haloperidol?
MediHelp also lists interactions of Haloperidol with, for example, Dofetilide, Dronedarone, Ibutilide. The full list is on the Haloperidol page.
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