Drug interactions
Dacomitinib + Liposomal doxorubicin
Severity: Minor
Dacomitinib and Liposomal doxorubicin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6, and doxorubicin is a minor CYP2D6 substrate. A clinically meaningful increase in doxorubicin exposure is possible but unproven.
What this interaction means in plain words
Dacomitinib and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Dacomitinib belongs to Oncology; Liposomal doxorubicin belongs to Oncology.
Why it happens
Dacomitinib inhibits CYP2D6, potentially slowing a minor doxorubicin metabolic pathway.
What to do
No empirical dose change is needed; monitor for myelosuppression and cardiotoxicity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Liposomal doxorubicin
- Dengue vaccine + Liposomal doxorubicin Contraindicated
- Belatacept + Liposomal doxorubicin Major
- Cyclosporine + Liposomal doxorubicin Major
- Dronedarone + Liposomal doxorubicin Major
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Liposomal doxorubicin Major
- Fingolimod + Liposomal doxorubicin Major
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Liposomal doxorubicin?
MediHelp rates the interaction as minor. Dacomitinib and Liposomal doxorubicin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Dacomitinib strongly inhibits CYP2D6, and doxorubicin is a minor CYP2D6 substrate. A clinically meaningful increase in doxorubicin exposure is possible but unproven.
How serious is the interaction between Dacomitinib and Liposomal doxorubicin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No empirical dose change is needed; monitor for myelosuppression and cardiotoxicity.
What other medicines interact with Liposomal doxorubicin?
MediHelp also lists interactions of Liposomal doxorubicin with, for example, Dengue vaccine, Belatacept, Cyclosporine. The full list is on the Liposomal doxorubicin page.
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