Drug interactions
Dacomitinib + Metoprolol
Severity: Moderate
Dacomitinib and Metoprolol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib strongly inhibits CYP2D6 and can markedly increase exposure to metoprolol, a CYP2D6 substrate. This may cause bradycardia, hypotension and fatigue.
What this interaction means in plain words
Dacomitinib and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacomitinib belongs to Oncology; Metoprolol belongs to Cardiovascular.
Why it happens
Inhibition of CYP2D6-mediated metoprolol metabolism by dacomitinib.
What to do
Monitor heart rate and blood pressure, and reduce the metoprolol dose if needed. Consider a beta-blocker not dependent on CYP2D6, such as bisoprolol or atenolol.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Metoprolol
- Metoprolol + Thioridazine Contraindicated
- Amifostine + Metoprolol Major
- Amiodarone + Metoprolol Major
- Atenolol-chlorthalidone + Metoprolol Major
- Atenolol + Metoprolol Major
- Betaxolol + Metoprolol Major
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Metoprolol?
MediHelp rates the interaction as moderate. Dacomitinib and Metoprolol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib strongly inhibits CYP2D6 and can markedly increase exposure to metoprolol, a CYP2D6 substrate. This may cause bradycardia, hypotension and fatigue.
How serious is the interaction between Dacomitinib and Metoprolol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate and blood pressure, and reduce the metoprolol dose if needed. Consider a beta-blocker not dependent on CYP2D6, such as bisoprolol or atenolol.
What other medicines interact with Metoprolol?
MediHelp also lists interactions of Metoprolol with, for example, Thioridazine, Amifostine, Amiodarone. The full list is on the Metoprolol page.
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