Drug interactions
Dacomitinib + Perphenazine
Severity: Moderate
Dacomitinib and Perphenazine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dacomitinib is a strong CYP2D6 inhibitor, and perphenazine is cleared mainly by CYP2D6. Perphenazine exposure may rise substantially, increasing sedation, extrapyramidal effects and QT-related risk.
What this interaction means in plain words
Dacomitinib and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dacomitinib belongs to Oncology; Perphenazine belongs to Central Nervous System.
Why it happens
Inhibition of CYP2D6-mediated metabolism of perphenazine by dacomitinib.
What to do
Monitor for perphenazine adverse effects such as extrapyramidal symptoms and sedation, and reduce the perphenazine dose if they occur. Consider an antipsychotic not dependent on CYP2D6.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Perphenazine
- Ibutilide + Perphenazine Contraindicated
- Perphenazine + Pimozide Contraindicated
- Perphenazine + Thioridazine Contraindicated
- Adagrasib + Perphenazine Major
- Alfentanil + Perphenazine Major
- Amiodarone + Perphenazine Major
Other interactions of Dacomitinib
- Dacomitinib + Thioridazine Contraindicated
- Amitriptyline + Dacomitinib Major
- Atomoxetine + Dacomitinib Major
- Brexpiprazole + Dacomitinib Major
- Clomipramine + Dacomitinib Major
- Dacomitinib + Desipramine Major
Frequently asked questions
Can I take Dacomitinib with Perphenazine?
MediHelp rates the interaction as moderate. Dacomitinib and Perphenazine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dacomitinib is a strong CYP2D6 inhibitor, and perphenazine is cleared mainly by CYP2D6. Perphenazine exposure may rise substantially, increasing sedation, extrapyramidal effects and QT-related risk.
How serious is the interaction between Dacomitinib and Perphenazine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for perphenazine adverse effects such as extrapyramidal symptoms and sedation, and reduce the perphenazine dose if they occur. Consider an antipsychotic not dependent on CYP2D6.
What other medicines interact with Perphenazine?
MediHelp also lists interactions of Perphenazine with, for example, Ibutilide, Pimozide, Thioridazine. The full list is on the Perphenazine page.
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