Drug interactions
Dactinomycin + Levoketoconazole
Severity: Moderate
Dactinomycin and Levoketoconazole: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levoketoconazole inhibits P-glycoprotein and may increase dactinomycin exposure, raising the risk of myelosuppression, mucositis and liver toxicity.
What this interaction means in plain words
Dactinomycin and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dactinomycin belongs to Oncology; Levoketoconazole belongs to Endocrine.
Why it happens
Inhibition of P-glycoprotein efflux of dactinomycin.
What to do
Monitor blood counts and liver function closely, and consider an alternative to the azole during dactinomycin therapy.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dactinomycin
- Adenovirus types 4 and 7 live + Dactinomycin Contraindicated
- Belatacept + Dactinomycin Major
- Dactinomycin + Dengue vaccine Major
- Dactinomycin + Etrasimod Major
- Dactinomycin + Fingolimod Major
- Dactinomycin + Palifermin Major
Other interactions of Levoketoconazole
- Alfuzosin + Levoketoconazole Contraindicated
- Alprazolam + Levoketoconazole Contraindicated
- Amiodarone + Levoketoconazole Contraindicated
- Avanafil + Levoketoconazole Contraindicated
- Cisapride + Levoketoconazole Contraindicated
- Clarithromycin + Levoketoconazole Contraindicated
Frequently asked questions
Can I take Dactinomycin with Levoketoconazole?
MediHelp rates the interaction as moderate. Dactinomycin and Levoketoconazole can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levoketoconazole inhibits P-glycoprotein and may increase dactinomycin exposure, raising the risk of myelosuppression, mucositis and liver toxicity.
How serious is the interaction between Dactinomycin and Levoketoconazole?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and liver function closely, and consider an alternative to the azole during dactinomycin therapy.
What other medicines interact with Dactinomycin?
MediHelp also lists interactions of Dactinomycin with, for example, Adenovirus types 4 and 7 live, Belatacept, Dengue vaccine. The full list is on the Dactinomycin page.
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