Drug interactions
Dalteparin + Fondaparinux
Severity: Major
Dalteparin and Fondaparinux: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both agents are parenteral anticoagulants acting through antithrombin-mediated inhibition of clotting factors. Using them together adds to the anticoagulant effect and raises the risk of serious bleeding without any therapeutic advantage.
What this interaction means in plain words
Dalteparin and Fondaparinux can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalteparin belongs to Cardiovascular; Fondaparinux belongs to Cardiovascular.
Why it happens
Additive pharmacodynamic anticoagulation through antithrombin-dependent inhibition of factor Xa.
What to do
Avoid concurrent use and give only one parenteral anticoagulant at a time, switching at the time the next dose is due. Monitor for bleeding if a transition between agents is required.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Fondaparinux
- Defibrotide + Fondaparinux Contraindicated
- Fondaparinux + Ketorolac Contraindicated
- Abciximab + Fondaparinux Major
- Aceclofenac + Fondaparinux Major
- Acetylsalicylic acid + Fondaparinux Major
- Alteplase + Fondaparinux Major
Frequently asked questions
Can I take Dalteparin with Fondaparinux?
MediHelp rates the interaction as major. Dalteparin and Fondaparinux can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both agents are parenteral anticoagulants acting through antithrombin-mediated inhibition of clotting factors. Using them together adds to the anticoagulant effect and raises the risk of serious bleeding without any therapeutic advantage.
How serious is the interaction between Dalteparin and Fondaparinux?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use and give only one parenteral anticoagulant at a time, switching at the time the next dose is due. Monitor for bleeding if a transition between agents is required.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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