Drug interactions
Dalteparin + Gemcitabine
Severity: Moderate
Dalteparin and Gemcitabine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gemcitabine can cause thrombocytopenia and, uncommonly, haemorrhage. Combined with dalteparin, the risk of bleeding rises during periods of low platelets.
What this interaction means in plain words
Dalteparin and Gemcitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Gemcitabine belongs to Oncology.
Why it happens
Additive bleeding risk from gemcitabine myelosuppression and dalteparin anticoagulation.
What to do
Check platelet counts regularly and adjust or hold dalteparin if thrombocytopenia becomes significant. Monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Gemcitabine
Frequently asked questions
Can I take Dalteparin with Gemcitabine?
MediHelp rates the interaction as moderate. Dalteparin and Gemcitabine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gemcitabine can cause thrombocytopenia and, uncommonly, haemorrhage. Combined with dalteparin, the risk of bleeding rises during periods of low platelets.
How serious is the interaction between Dalteparin and Gemcitabine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check platelet counts regularly and adjust or hold dalteparin if thrombocytopenia becomes significant. Monitor for bleeding.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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