Drug interactions
Dalteparin + Losartan
Severity: Moderate
Dalteparin and Losartan: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Low molecular weight heparins can suppress aldosterone secretion, and when combined with an angiotensin receptor blocker the risk of hyperkalemia rises. This is most relevant in patients with renal impairment, diabetes or prolonged use.
What this interaction means in plain words
Dalteparin and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Losartan belongs to Cardiovascular.
Why it happens
Heparin-induced inhibition of adrenal aldosterone synthesis adds to the reduction of potassium excretion from angiotensin receptor blockade.
What to do
Monitor serum potassium in patients on prolonged therapy or with risk factors such as renal impairment or diabetes.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Losartan
- Aliskiren + Losartan Contraindicated
- Losartan + Sparsentan Contraindicated
- Amifostine + Losartan Major
- Amiloride + Losartan Major
- Amlodipine-benazepril + Losartan Major
- Amlodipine-hydrochlorothiazide-valsartan + Losartan Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Losartan?
MediHelp rates the interaction as moderate. Dalteparin and Losartan can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Low molecular weight heparins can suppress aldosterone secretion, and when combined with an angiotensin receptor blocker the risk of hyperkalemia rises. This is most relevant in patients with renal impairment, diabetes or prolonged use.
How serious is the interaction between Dalteparin and Losartan?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium in patients on prolonged therapy or with risk factors such as renal impairment or diabetes.
What other medicines interact with Losartan?
MediHelp also lists interactions of Losartan with, for example, Aliskiren, Sparsentan, Amifostine. The full list is on the Losartan page.
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