Drug interactions
Dalteparin + Nabumetone
Severity: Major
Dalteparin and Nabumetone: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Low molecular weight heparin plus an NSAID increases bleeding risk through combined effects on coagulation and platelet function. Gastrointestinal bleeding is of particular concern.
What this interaction means in plain words
Dalteparin and Nabumetone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalteparin belongs to Cardiovascular; Nabumetone belongs to Musculoskeletal.
Why it happens
Additive pharmacodynamic effect of anticoagulation and NSAID-induced platelet inhibition and mucosal injury.
What to do
Avoid combination when possible and choose a non-NSAID analgesic such as paracetamol; if used, monitor for bleeding and hemoglobin.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Nabumetone
- Ketorolac intranasal + Nabumetone Contraindicated
- Ketorolac + Nabumetone Contraindicated
- Aceclofenac + Nabumetone Major
- Acemetacin + Nabumetone Major
- Acetylsalicylic acid + Nabumetone Major
- Alteplase + Nabumetone Major
Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Frequently asked questions
Can I take Dalteparin with Nabumetone?
MediHelp rates the interaction as major. Dalteparin and Nabumetone can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Low molecular weight heparin plus an NSAID increases bleeding risk through combined effects on coagulation and platelet function. Gastrointestinal bleeding is of particular concern.
How serious is the interaction between Dalteparin and Nabumetone?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination when possible and choose a non-NSAID analgesic such as paracetamol; if used, monitor for bleeding and hemoglobin.
What other medicines interact with Nabumetone?
MediHelp also lists interactions of Nabumetone with, for example, Ketorolac intranasal, Ketorolac, Aceclofenac. The full list is on the Nabumetone page.
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