Drug interactions
Dalteparin + Pegaspargase
Severity: Moderate
Dalteparin and Pegaspargase: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Pegaspargase reduces synthesis of coagulation factors and anticoagulant proteins, causing both bleeding and thrombosis. Together with dalteparin, bleeding risk may rise, and the effect on thrombosis prophylaxis is unpredictable.
What this interaction means in plain words
Dalteparin and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dalteparin belongs to Cardiovascular; Pegaspargase belongs to Oncology.
Why it happens
Pegaspargase-induced hypofibrinogenemia and coagulation factor depletion add to heparin anticoagulant effect.
What to do
Monitor fibrinogen, platelet count and coagulation parameters, and watch for bleeding. Adjust or hold dalteparin if significant coagulopathy or low platelets occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Pegaspargase
- Etodolac + Pegaspargase Major
- Ketorolac + Pegaspargase Major
- Mefenamic acid + Pegaspargase Major
- Acetylsalicylic acid + Pegaspargase Moderate
- Argatroban + Pegaspargase Moderate
- Celecoxib + Pegaspargase Moderate
Frequently asked questions
Can I take Dalteparin with Pegaspargase?
MediHelp rates the interaction as moderate. Dalteparin and Pegaspargase can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Pegaspargase reduces synthesis of coagulation factors and anticoagulant proteins, causing both bleeding and thrombosis. Together with dalteparin, bleeding risk may rise, and the effect on thrombosis prophylaxis is unpredictable.
How serious is the interaction between Dalteparin and Pegaspargase?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor fibrinogen, platelet count and coagulation parameters, and watch for bleeding. Adjust or hold dalteparin if significant coagulopathy or low platelets occur.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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