Drug interactions
Dalteparin + Rivaroxaban
Severity: Major
Dalteparin and Rivaroxaban: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Giving a low molecular weight heparin together with a factor Xa inhibitor produces overlapping anticoagulation and a clearly higher chance of serious bleeding. Overlap is acceptable only when switching from one agent to the other.
What this interaction means in plain words
Dalteparin and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalteparin belongs to Cardiovascular; Rivaroxaban belongs to Cardiovascular.
Why it happens
Additive anticoagulant effect through antithrombin-mediated factor Xa inhibition by dalteparin and direct factor Xa inhibition by rivaroxaban.
What to do
Avoid concurrent use except during planned transitions, starting rivaroxaban when the next dalteparin dose would be due. Monitor for bleeding and check haemoglobin if overlap occurs.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Rivaroxaban
- Defibrotide + Rivaroxaban Contraindicated
- Ketoconazole + Rivaroxaban Contraindicated
- Ketorolac + Rivaroxaban Contraindicated
- Abciximab + Rivaroxaban Major
- Acalabrutinib + Rivaroxaban Major
- Acetylsalicylic acid + Rivaroxaban Major
Frequently asked questions
Can I take Dalteparin with Rivaroxaban?
MediHelp rates the interaction as major. Dalteparin and Rivaroxaban can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Giving a low molecular weight heparin together with a factor Xa inhibitor produces overlapping anticoagulation and a clearly higher chance of serious bleeding. Overlap is acceptable only when switching from one agent to the other.
How serious is the interaction between Dalteparin and Rivaroxaban?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use except during planned transitions, starting rivaroxaban when the next dalteparin dose would be due. Monitor for bleeding and check haemoglobin if overlap occurs.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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