Drug interactions
Dalteparin + Tipranavir
Severity: Major
Dalteparin and Tipranavir: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tipranavir boosted with ritonavir has been associated with intracranial hemorrhage and has mild antiplatelet activity. With dalteparin the bleeding risk may increase.
What this interaction means in plain words
Dalteparin and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dalteparin belongs to Cardiovascular; Tipranavir belongs to Anti Virals.
Why it happens
Additive pharmacodynamic effect from tipranavir antiplatelet activity and anticoagulation.
What to do
Avoid combination where alternatives exist; if used, monitor closely for bleeding and neurological symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dalteparin
- Dalteparin + Defibrotide Contraindicated
- Dalteparin + Ketorolac Contraindicated
- Dalteparin + Mifepristone Contraindicated
- Abciximab + Dalteparin Major
- Acalabrutinib + Dalteparin Major
- Aceclofenac + Dalteparin Major
Other interactions of Tipranavir
- Alfuzosin + Tipranavir Contraindicated
- Amiodarone + Tipranavir Contraindicated
- Atorvastatin + Tipranavir Contraindicated
- Avanafil + Tipranavir Contraindicated
- Cisapride + Tipranavir Contraindicated
- Colchicine + Tipranavir Contraindicated
Frequently asked questions
Can I take Dalteparin with Tipranavir?
MediHelp rates the interaction as major. Dalteparin and Tipranavir can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tipranavir boosted with ritonavir has been associated with intracranial hemorrhage and has mild antiplatelet activity. With dalteparin the bleeding risk may increase.
How serious is the interaction between Dalteparin and Tipranavir?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid combination where alternatives exist; if used, monitor closely for bleeding and neurological symptoms.
What other medicines interact with Dalteparin?
MediHelp also lists interactions of Dalteparin with, for example, Defibrotide, Ketorolac, Mifepristone. The full list is on the Dalteparin page.
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