Drug interactions
Danazol + Fenofibrate
Severity: Minor
Danazol and Fenofibrate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol inhibits CYP3A4, but fenofibrate relies on it only minimally, so exposure is not expected to change much. Both drugs can affect lipids and liver enzymes, so the more relevant concern is additive adverse effects. Danazol tends to lower HDL cholesterol, which opposes the fibrate's benefit.
What this interaction means in plain words
Danazol and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Weak CYP3A4 inhibition by danazol with limited effect on fenofibric acid clearance, plus overlapping effects on lipids and liver tests.
What to do
No dose adjustment is required. Monitor lipids and liver enzymes during combined therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Fenofibrate
- Atorvastatin + Fenofibrate Moderate
- Cholestyramine + Fenofibrate Moderate
- Cholic acid + Fenofibrate Moderate
- Colchicine + Fenofibrate Moderate
- Colestipol + Fenofibrate Moderate
- Cyclosporine + Fenofibrate Moderate
Frequently asked questions
Can I take Danazol with Fenofibrate?
MediHelp rates the interaction as minor. Danazol and Fenofibrate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol inhibits CYP3A4, but fenofibrate relies on it only minimally, so exposure is not expected to change much. Both drugs can affect lipids and liver enzymes, so the more relevant concern is additive adverse effects. Danazol tends to lower HDL cholesterol, which opposes the fibrate's benefit.
How serious is the interaction between Danazol and Fenofibrate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is required. Monitor lipids and liver enzymes during combined therapy.
What other medicines interact with Fenofibrate?
MediHelp also lists interactions of Fenofibrate with, for example, Atorvastatin, Cholestyramine, Cholic acid. The full list is on the Fenofibrate page.
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