Drug interactions
Danazol + Rolapitant
Severity: Minor
Danazol and Rolapitant: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danazol is a moderate CYP3A4 inhibitor and may increase rolapitant exposure. The clinical consequence is uncertain given rolapitant's wide tolerability.
What this interaction means in plain words
Danazol and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Inhibition of CYP3A4 by danazol decreases rolapitant metabolism.
What to do
No routine adjustment is needed. Monitor for adverse effects such as headache or dizziness.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Rolapitant
- Pimozide + Rolapitant Contraindicated
- Rolapitant + Thioridazine Contraindicated
- Atomoxetine + Rolapitant Major
- Deutetrabenazine + Rolapitant Major
- Eliglustat + Rolapitant Major
- Flecainide + Rolapitant Major
Frequently asked questions
Can I take Danazol with Rolapitant?
MediHelp rates the interaction as minor. Danazol and Rolapitant have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danazol is a moderate CYP3A4 inhibitor and may increase rolapitant exposure. The clinical consequence is uncertain given rolapitant's wide tolerability.
How serious is the interaction between Danazol and Rolapitant?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed. Monitor for adverse effects such as headache or dizziness.
What other medicines interact with Rolapitant?
MediHelp also lists interactions of Rolapitant with, for example, Pimozide, Thioridazine, Atomoxetine. The full list is on the Rolapitant page.
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