Drug interactions
Danicopan + Imatinib
Severity: Moderate
Danicopan and Imatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-gp and BCRP, and may increase imatinib absorption and exposure. This could increase imatinib adverse effects such as edema, cytopenias and gastrointestinal toxicity.
What this interaction means in plain words
Danicopan and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Imatinib belongs to Oncology.
Why it happens
Danicopan inhibits intestinal P-gp and BCRP efflux of imatinib.
What to do
Monitor for imatinib toxicity and blood counts, and consider an imatinib dose reduction if adverse effects occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Imatinib
- Imatinib + Lomitapide Contraindicated
- Imatinib + Lonafarnib Contraindicated
- Amobarbital + Imatinib Major
- Apalutamide + Imatinib Major
- Avapritinib + Imatinib Major
- Benzhydrocodone / acetaminophen + Imatinib Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Imatinib?
MediHelp rates the interaction as moderate. Danicopan and Imatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-gp and BCRP, and may increase imatinib absorption and exposure. This could increase imatinib adverse effects such as edema, cytopenias and gastrointestinal toxicity.
How serious is the interaction between Danicopan and Imatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for imatinib toxicity and blood counts, and consider an imatinib dose reduction if adverse effects occur.
What other medicines interact with Imatinib?
MediHelp also lists interactions of Imatinib with, for example, Lomitapide, Lonafarnib, Amobarbital. The full list is on the Imatinib page.
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