Drug interactions
Danicopan + Lapatinib
Severity: Moderate
Danicopan and Lapatinib: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and BCRP, both involved in lapatinib transport. Lapatinib exposure may therefore increase, raising the risk of diarrhea, hepatotoxicity and QT prolongation.
What this interaction means in plain words
Danicopan and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Lapatinib belongs to Oncology.
Why it happens
Danicopan inhibits P-glycoprotein and BCRP efflux transporters, increasing lapatinib absorption.
What to do
Monitor for lapatinib toxicity, including liver tests and ECG, and consider a lapatinib dose reduction if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Lapatinib
- Dofetilide + Lapatinib Contraindicated
- Ibutilide + Lapatinib Contraindicated
- Lapatinib + Pimozide Contraindicated
- Lapatinib + Saquinavir Contraindicated
- Lapatinib + Thioridazine Contraindicated
- Adagrasib + Lapatinib Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Lapatinib?
MediHelp rates the interaction as moderate. Danicopan and Lapatinib can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and BCRP, both involved in lapatinib transport. Lapatinib exposure may therefore increase, raising the risk of diarrhea, hepatotoxicity and QT prolongation.
How serious is the interaction between Danicopan and Lapatinib?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for lapatinib toxicity, including liver tests and ECG, and consider a lapatinib dose reduction if adverse effects emerge.
What other medicines interact with Lapatinib?
MediHelp also lists interactions of Lapatinib with, for example, Dofetilide, Ibutilide, Pimozide. The full list is on the Lapatinib page.
Full monographs, dosing and an interaction checker in the MediHelp app
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