Drug interactions
Danicopan + Linagliptin-metformin
Severity: Minor
Danicopan and Linagliptin-metformin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and may increase exposure to linagliptin, which is a P-gp substrate. Because linagliptin has a wide safety margin, the clinical impact is probably small.
What this interaction means in plain words
Danicopan and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Danicopan belongs to Miscellaneous; Linagliptin-metformin belongs to Endocrine.
Why it happens
Inhibition of intestinal P-glycoprotein efflux by danicopan increases linagliptin absorption.
What to do
No dose adjustment is usually needed; watch for linagliptin adverse effects such as pancreatitis symptoms or hypersensitivity.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Linagliptin-metformin
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Linagliptin-metformin?
MediHelp rates the interaction as minor. Danicopan and Linagliptin-metformin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Danicopan inhibits P-glycoprotein and may increase exposure to linagliptin, which is a P-gp substrate. Because linagliptin has a wide safety margin, the clinical impact is probably small.
How serious is the interaction between Danicopan and Linagliptin-metformin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose adjustment is usually needed; watch for linagliptin adverse effects such as pancreatitis symptoms or hypersensitivity.
What other medicines interact with Linagliptin-metformin?
MediHelp also lists interactions of Linagliptin-metformin with, for example, Apalutamide, Carbamazepine, Contrast media. The full list is on the Linagliptin-metformin page.
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