Drug interactions
Danicopan + Mitoxantrone
Severity: Moderate
Danicopan and Mitoxantrone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits BCRP and can increase exposure to BCRP substrates such as mitoxantrone. This may worsen myelosuppression and cardiotoxicity.
What this interaction means in plain words
Danicopan and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Mitoxantrone belongs to Central Nervous System.
Why it happens
Inhibition of BCRP efflux transport by danicopan reduces mitoxantrone clearance.
What to do
Monitor blood counts and consider mitoxantrone dose reduction while on danicopan.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Mitoxantrone
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Mitoxantrone?
MediHelp rates the interaction as moderate. Danicopan and Mitoxantrone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits BCRP and can increase exposure to BCRP substrates such as mitoxantrone. This may worsen myelosuppression and cardiotoxicity.
How serious is the interaction between Danicopan and Mitoxantrone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood counts and consider mitoxantrone dose reduction while on danicopan.
What other medicines interact with Mitoxantrone?
MediHelp also lists interactions of Mitoxantrone with, for example, Adenovirus types 4 and 7 live, Axicabtagene ciloleucel, Belatacept. The full list is on the Mitoxantrone page.
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