Drug interactions
Danicopan + Nicardipine
Severity: Moderate
Danicopan and Nicardipine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and may increase exposure to P-gp substrates. Nicardipine is a P-gp substrate so its effects may be enhanced, though the clinical size of this effect is not well defined.
What this interaction means in plain words
Danicopan and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Nicardipine belongs to Cardiovascular.
Why it happens
Danicopan inhibits P-glycoprotein efflux, potentially increasing nicardipine absorption and reducing elimination.
What to do
Monitor blood pressure and heart rate after danicopan initiation, and lower the nicardipine dose if hypotension or edema occurs.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nicardipine
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Nicardipine?
MediHelp rates the interaction as moderate. Danicopan and Nicardipine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and may increase exposure to P-gp substrates. Nicardipine is a P-gp substrate so its effects may be enhanced, though the clinical size of this effect is not well defined.
How serious is the interaction between Danicopan and Nicardipine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure and heart rate after danicopan initiation, and lower the nicardipine dose if hypotension or edema occurs.
What other medicines interact with Nicardipine?
MediHelp also lists interactions of Nicardipine with, for example, Amifostine, Amlodipine-olmesartan-hydrochlorothiazide, Betrixaban. The full list is on the Nicardipine page.
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