Drug interactions
Danicopan + Simvastatin
Severity: Moderate
Danicopan and Simvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits BCRP and P-gp and raised exposure of rosuvastatin in studies. Simvastatin exposure may also increase, raising the risk of myopathy.
What this interaction means in plain words
Danicopan and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Simvastatin belongs to Cardiovascular.
Why it happens
Danicopan inhibits intestinal BCRP/P-gp efflux, increasing statin absorption.
What to do
Monitor for muscle pain, weakness or dark urine and use the lowest effective simvastatin dose. Check creatine kinase if symptoms occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Simvastatin
- Atazanavir + Simvastatin Contraindicated
- Clarithromycin + Simvastatin Contraindicated
- Cobicistat + Simvastatin Contraindicated
- Cyclosporine + Simvastatin Contraindicated
- Cyclosporin + Simvastatin Contraindicated
- Danazol + Simvastatin Contraindicated
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Simvastatin?
MediHelp rates the interaction as moderate. Danicopan and Simvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits BCRP and P-gp and raised exposure of rosuvastatin in studies. Simvastatin exposure may also increase, raising the risk of myopathy.
How serious is the interaction between Danicopan and Simvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle pain, weakness or dark urine and use the lowest effective simvastatin dose. Check creatine kinase if symptoms occur.
What other medicines interact with Simvastatin?
MediHelp also lists interactions of Simvastatin with, for example, Atazanavir, Clarithromycin, Cobicistat. The full list is on the Simvastatin page.
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