Drug interactions
Danicopan + Verapamil
Severity: Moderate
Danicopan and Verapamil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danicopan inhibits P-glycoprotein and may raise verapamil concentrations. This could increase hypotension, bradycardia and conduction delay.
What this interaction means in plain words
Danicopan and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Danicopan belongs to Miscellaneous; Verapamil belongs to Cardiovascular.
Why it happens
Danicopan inhibits intestinal P-glycoprotein, increasing absorption of verapamil.
What to do
Monitor heart rate, blood pressure and ECG, and consider reducing the verapamil dose if adverse effects emerge.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Verapamil
- Dofetilide + Verapamil Contraindicated
- Flibanserin + Verapamil Contraindicated
- Lomitapide + Verapamil Contraindicated
- Lonafarnib + Verapamil Contraindicated
- Pimozide + Verapamil Contraindicated
- Acebutolol + Verapamil Major
Other interactions of Danicopan
- Amiodarone + Danicopan Moderate
- Apixaban + Danicopan Moderate
- Atorvastatin + Danicopan Moderate
- Brentuximab + Danicopan Moderate
- Carvedilol + Danicopan Moderate
- Cladribine + Danicopan Moderate
Frequently asked questions
Can I take Danicopan with Verapamil?
MediHelp rates the interaction as moderate. Danicopan and Verapamil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danicopan inhibits P-glycoprotein and may raise verapamil concentrations. This could increase hypotension, bradycardia and conduction delay.
How serious is the interaction between Danicopan and Verapamil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor heart rate, blood pressure and ECG, and consider reducing the verapamil dose if adverse effects emerge.
What other medicines interact with Verapamil?
MediHelp also lists interactions of Verapamil with, for example, Dofetilide, Flibanserin, Lomitapide. The full list is on the Verapamil page.
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