Drug interactions
Dantrolene + Desipramine
Severity: Moderate
Dantrolene and Desipramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Desipramine is a tricyclic antidepressant that can cause sedation, though it is among the less sedating tricyclics. Added to dantrolene, which also causes drowsiness, the combination may increase sedation and dizziness.
What this interaction means in plain words
Dantrolene and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Desipramine belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for sedation, dizziness and orthostatic hypotension, and adjust doses if impairment develops. Counsel patients about driving and operating machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Desipramine
- Desipramine + Disopyramide Contraindicated
- Desipramine + Dofetilide Contraindicated
- Desipramine + Ibutilide Contraindicated
- Desipramine + Isocarboxazid Contraindicated
- Desipramine + Methylene blue Contraindicated
- Desipramine + Pentamidine Contraindicated
Frequently asked questions
Can I take Dantrolene with Desipramine?
MediHelp rates the interaction as moderate. Dantrolene and Desipramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Desipramine is a tricyclic antidepressant that can cause sedation, though it is among the less sedating tricyclics. Added to dantrolene, which also causes drowsiness, the combination may increase sedation and dizziness.
How serious is the interaction between Dantrolene and Desipramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation, dizziness and orthostatic hypotension, and adjust doses if impairment develops. Counsel patients about driving and operating machinery.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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