Drug interactions
Dantrolene + Doxepin
Severity: Moderate
Dantrolene and Doxepin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Doxepin is a sedating tricyclic antidepressant with strong antihistaminic effects, and dantrolene also causes drowsiness and weakness. Together they can increase sedation, dizziness and psychomotor impairment.
What this interaction means in plain words
Dantrolene and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Doxepin belongs to Dermatology.
Why it happens
Additive CNS depression from histamine H1 blockade by doxepin and dantrolene sedation.
What to do
Monitor for excessive sedation and falls, especially in older adults, and consider lower starting doses. Advise avoiding alcohol and driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Doxepin
- Doxepin + Isocarboxazid Contraindicated
- Doxepin + Phenelzine Contraindicated
- Doxepin + Procarbazine Contraindicated
- Doxepin + Safinamide Contraindicated
- Doxepin + Selegiline Contraindicated
- Doxepin + Tranylcypromine Contraindicated
Frequently asked questions
Can I take Dantrolene with Doxepin?
MediHelp rates the interaction as moderate. Dantrolene and Doxepin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Doxepin is a sedating tricyclic antidepressant with strong antihistaminic effects, and dantrolene also causes drowsiness and weakness. Together they can increase sedation, dizziness and psychomotor impairment.
How serious is the interaction between Dantrolene and Doxepin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive sedation and falls, especially in older adults, and consider lower starting doses. Advise avoiding alcohol and driving until tolerance is established.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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