Drug interactions
Dantrolene + Hydrocodone
Severity: Moderate
Dantrolene and Hydrocodone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene can cause drowsiness and dizziness, which may add to hydrocodone's sedation. The effect is usually modest at oral doses.
What this interaction means in plain words
Dantrolene and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Hydrocodone belongs to Musculoskeletal.
Why it happens
Additive CNS depression and sedation; dantrolene acts mainly peripherally on muscle, with some central effects.
What to do
Monitor for excessive drowsiness and respiratory depression, and use the lowest effective hydrocodone dose. Advise against driving until the response is known.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocodone
- Alvimopan + Hydrocodone Contraindicated
- Bupropion-naltrexone + Hydrocodone Contraindicated
- Hydrocodone + Isocarboxazid Contraindicated
- Hydrocodone + Olanzapine / samidorphan Contraindicated
- Hydrocodone + Phenelzine Contraindicated
- Alfentanil + Hydrocodone Major
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Hydrocodone?
MediHelp rates the interaction as moderate. Dantrolene and Hydrocodone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene can cause drowsiness and dizziness, which may add to hydrocodone's sedation. The effect is usually modest at oral doses.
How serious is the interaction between Dantrolene and Hydrocodone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excessive drowsiness and respiratory depression, and use the lowest effective hydrocodone dose. Advise against driving until the response is known.
What other medicines interact with Hydrocodone?
MediHelp also lists interactions of Hydrocodone with, for example, Alvimopan, Bupropion-naltrexone, Isocarboxazid. The full list is on the Hydrocodone page.
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