Drug interactions
Dantrolene + Lenacapavir
Severity: Moderate
Dantrolene and Lenacapavir: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lenacapavir is a moderate CYP3A inhibitor, and dantrolene is partly metabolized by CYP3A4. Dantrolene exposure may rise, increasing sedation, weakness and the potential for liver toxicity, and the inhibition can persist for months after the last injection.
What this interaction means in plain words
Dantrolene and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Lenacapavir belongs to Anti Virals.
Why it happens
Lenacapavir inhibits CYP3A4, reducing dantrolene metabolism.
What to do
Monitor for dantrolene adverse effects and liver enzymes, and reduce the dantrolene dose if needed. Remember the inhibitory effect may persist after lenacapavir injections.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Lenacapavir
- Apalutamide + Lenacapavir Contraindicated
- Carbamazepine + Lenacapavir Contraindicated
- Enzalutamide + Lenacapavir Contraindicated
- Flibanserin + Lenacapavir Contraindicated
- Lenacapavir + Phenytoin Contraindicated
- Lenacapavir + Rifampicin Contraindicated
Frequently asked questions
Can I take Dantrolene with Lenacapavir?
MediHelp rates the interaction as moderate. Dantrolene and Lenacapavir can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lenacapavir is a moderate CYP3A inhibitor, and dantrolene is partly metabolized by CYP3A4. Dantrolene exposure may rise, increasing sedation, weakness and the potential for liver toxicity, and the inhibition can persist for months after the last injection.
How serious is the interaction between Dantrolene and Lenacapavir?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for dantrolene adverse effects and liver enzymes, and reduce the dantrolene dose if needed. Remember the inhibitory effect may persist after lenacapavir injections.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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