Drug interactions
Dantrolene + Levetiracetam
Severity: Moderate
Dantrolene and Levetiracetam: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Levetiracetam frequently causes somnolence and dizziness, and dantrolene has similar effects. Together they may increase drowsiness and impair coordination.
What this interaction means in plain words
Dantrolene and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Levetiracetam belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for increased sedation and dizziness, especially when starting or raising doses. Advise patients to avoid driving until tolerance is established.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Dantrolene and Levetiracetam, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 14 days on the web. No card needed.
Other interactions of Dantrolene
Other interactions of Levetiracetam
Frequently asked questions
Can I take Dantrolene with Levetiracetam?
MediHelp rates the interaction as moderate. Dantrolene and Levetiracetam can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Levetiracetam frequently causes somnolence and dizziness, and dantrolene has similar effects. Together they may increase drowsiness and impair coordination.
How serious is the interaction between Dantrolene and Levetiracetam?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for increased sedation and dizziness, especially when starting or raising doses. Advise patients to avoid driving until tolerance is established.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
