Drug interactions
Dantrolene + Loxapine
Severity: Moderate
Dantrolene and Loxapine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Loxapine is a sedating antipsychotic and dantrolene commonly causes drowsiness. Combined use may increase central nervous system depression and impair alertness.
What this interaction means in plain words
Dantrolene and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Loxapine belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for oversedation and falls, and adjust doses if impairment occurs. Counsel patients about driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Loxapine
- Alfentanil + Loxapine Major
- Alprazolam + Loxapine Major
- Amisulpride + Loxapine Major
- Amoxapine + Loxapine Major
- Apomorphine + Loxapine Major
- Belladonna and opium + Loxapine Major
Frequently asked questions
Can I take Dantrolene with Loxapine?
MediHelp rates the interaction as moderate. Dantrolene and Loxapine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Loxapine is a sedating antipsychotic and dantrolene commonly causes drowsiness. Combined use may increase central nervous system depression and impair alertness.
How serious is the interaction between Dantrolene and Loxapine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and falls, and adjust doses if impairment occurs. Counsel patients about driving and machinery.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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