Drug interactions
Dantrolene + Methocarbamol
Severity: Moderate
Dantrolene and Methocarbamol: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene commonly causes drowsiness, dizziness and weakness, and methocarbamol adds central sedation. Together they may cause excessive sedation and muscle weakness, which may impair mobility and safety.
What this interaction means in plain words
Dantrolene and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Methocarbamol belongs to Musculoskeletal.
Why it happens
Additive sedation and muscle weakening, from central depression by methocarbamol and peripheral inhibition of calcium release by dantrolene.
What to do
Monitor for oversedation, weakness and falls. Avoid combining unless clearly needed, and counsel against driving.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Methocarbamol
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Methocarbamol?
MediHelp rates the interaction as moderate. Dantrolene and Methocarbamol can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene commonly causes drowsiness, dizziness and weakness, and methocarbamol adds central sedation. Together they may cause excessive sedation and muscle weakness, which may impair mobility and safety.
How serious is the interaction between Dantrolene and Methocarbamol?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation, weakness and falls. Avoid combining unless clearly needed, and counsel against driving.
What other medicines interact with Methocarbamol?
MediHelp also lists interactions of Methocarbamol with, for example, Alfentanil, Amobarbital, Belladonna and opium. The full list is on the Methocarbamol page.
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