Drug interactions
Dantrolene + Methohexital
Severity: Moderate
Dantrolene and Methohexital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene causes drowsiness and muscle weakness, and methohexital is a potent barbiturate anesthetic that causes dose-related CNS and respiratory depression. Used together, sedation and respiratory compromise can be greater than with either drug alone.
What this interaction means in plain words
Dantrolene and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Methohexital belongs to Central Nervous System.
Why it happens
Additive CNS depressant effects (pharmacodynamic synergism).
What to do
Titrate methohexital to effect with continuous monitoring of respiratory function and sedation depth, and reduce the dose if the patient is taking oral dantrolene. Ensure airway support is available.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Methohexital
Frequently asked questions
Can I take Dantrolene with Methohexital?
MediHelp rates the interaction as moderate. Dantrolene and Methohexital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene causes drowsiness and muscle weakness, and methohexital is a potent barbiturate anesthetic that causes dose-related CNS and respiratory depression. Used together, sedation and respiratory compromise can be greater than with either drug alone.
How serious is the interaction between Dantrolene and Methohexital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Titrate methohexital to effect with continuous monitoring of respiratory function and sedation depth, and reduce the dose if the patient is taking oral dantrolene. Ensure airway support is available.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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