Drug interactions
Dantrolene + Mitotane
Severity: Moderate
Dantrolene and Mitotane: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mitotane strongly induces CYP3A4, which participates in dantrolene metabolism through hepatic pathways. Dantrolene exposure may fall, reducing its effect. Induction can persist for weeks after mitotane is stopped.
What this interaction means in plain words
Dantrolene and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Mitotane belongs to Oncology.
Why it happens
Induction of CYP3A4 by mitotane increases dantrolene clearance.
What to do
Monitor for reduced antispastic or antihyperthermic response and adjust the dantrolene dose as needed. Continue monitoring after mitotane discontinuation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Mitotane
- Doravirine + Mitotane Contraindicated
- Fostemsavir + Mitotane Contraindicated
- Lorlatinib + Mitotane Contraindicated
- Abiraterone + Mitotane Major
- Apixaban + Mitotane Major
- Aprepitant + Mitotane Major
Frequently asked questions
Can I take Dantrolene with Mitotane?
MediHelp rates the interaction as moderate. Dantrolene and Mitotane can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mitotane strongly induces CYP3A4, which participates in dantrolene metabolism through hepatic pathways. Dantrolene exposure may fall, reducing its effect. Induction can persist for weeks after mitotane is stopped.
How serious is the interaction between Dantrolene and Mitotane?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for reduced antispastic or antihyperthermic response and adjust the dantrolene dose as needed. Continue monitoring after mitotane discontinuation.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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