Drug interactions
Dantrolene + Nalbuphine
Severity: Moderate
Dantrolene and Nalbuphine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene commonly causes drowsiness, dizziness and weakness, and these effects may add to nalbuphine sedation. The combination can impair alertness and coordination.
What this interaction means in plain words
Dantrolene and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Nalbuphine belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects; dantrolene also causes muscle weakness through peripheral action on the ryanodine receptor.
What to do
Monitor for sedation and weakness, using the lowest effective doses. Advise caution with driving and machinery.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Nalbuphine
- Alvimopan + Nalbuphine Contraindicated
- Nalbuphine + Olanzapine / samidorphan Contraindicated
- Alprazolam + Nalbuphine Major
- Amobarbital + Nalbuphine Major
- Benzhydrocodone / acetaminophen + Nalbuphine Major
- Brexanolone + Nalbuphine Major
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Nalbuphine?
MediHelp rates the interaction as moderate. Dantrolene and Nalbuphine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene commonly causes drowsiness, dizziness and weakness, and these effects may add to nalbuphine sedation. The combination can impair alertness and coordination.
How serious is the interaction between Dantrolene and Nalbuphine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for sedation and weakness, using the lowest effective doses. Advise caution with driving and machinery.
What other medicines interact with Nalbuphine?
MediHelp also lists interactions of Nalbuphine with, for example, Alvimopan, Olanzapine / samidorphan, Alprazolam. The full list is on the Nalbuphine page.
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