Drug interactions
Dantrolene + Oliceridine
Severity: Major
Dantrolene and Oliceridine: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Opioids combined with other CNS depressants can cause profound sedation, respiratory depression, coma and death. Dantrolene adds sedation and muscle weakness that may worsen ventilatory compromise.
What this interaction means in plain words
Dantrolene and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dantrolene belongs to Musculoskeletal; Oliceridine belongs to Musculoskeletal.
Why it happens
Additive CNS and respiratory depression from opioid and dantrolene.
What to do
Reserve combined use for patients lacking alternatives, using the lowest doses and shortest duration. Monitor closely for sedation and respiratory depression.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dantrolene
Other interactions of Oliceridine
- Isocarboxazid + Oliceridine Contraindicated
- Alprazolam + Oliceridine Major
- Amiodarone + Oliceridine Major
- Amisulpride + Oliceridine Major
- Amitriptyline + Oliceridine Major
- Amobarbital + Oliceridine Major
Frequently asked questions
Can I take Dantrolene with Oliceridine?
MediHelp rates the interaction as major. Dantrolene and Oliceridine can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Opioids combined with other CNS depressants can cause profound sedation, respiratory depression, coma and death. Dantrolene adds sedation and muscle weakness that may worsen ventilatory compromise.
How serious is the interaction between Dantrolene and Oliceridine?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Reserve combined use for patients lacking alternatives, using the lowest doses and shortest duration. Monitor closely for sedation and respiratory depression.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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