Drug interactions
Dantrolene + Orphenadrin
Severity: Moderate
Dantrolene and Orphenadrin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs can cause drowsiness, dizziness and weakness. Used together they may produce greater sedation and muscle weakness, increasing the risk of falls.
What this interaction means in plain words
Dantrolene and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Orphenadrin belongs to Musculoskeletal.
Why it happens
Additive central depressant and muscle relaxant effects.
What to do
Monitor for oversedation and excessive weakness and adjust doses accordingly. Counsel the patient about driving and fall precautions.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Orphenadrin
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Orphenadrin?
MediHelp rates the interaction as moderate. Dantrolene and Orphenadrin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs can cause drowsiness, dizziness and weakness. Used together they may produce greater sedation and muscle weakness, increasing the risk of falls.
How serious is the interaction between Dantrolene and Orphenadrin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and excessive weakness and adjust doses accordingly. Counsel the patient about driving and fall precautions.
What other medicines interact with Orphenadrin?
MediHelp also lists interactions of Orphenadrin with, for example, Alfentanil, Amobarbital, Benzhydrocodone / acetaminophen. The full list is on the Orphenadrin page.
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