Drug interactions
Dantrolene + Oxymorphone
Severity: Moderate
Dantrolene and Oxymorphone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene commonly causes drowsiness, dizziness and weakness, which can add to the sedative effects of opioids. Respiratory depression is a concern, particularly in patients with limited respiratory reserve.
What this interaction means in plain words
Dantrolene and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Oxymorphone belongs to Musculoskeletal.
Why it happens
Additive CNS depression and muscle weakness.
What to do
Monitor for oversedation and respiratory compromise, and begin with low opioid doses. Warn patients about impaired alertness.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Oxymorphone
- Alvimopan + Oxymorphone Contraindicated
- Ethanol + Oxymorphone Contraindicated
- Isocarboxazid + Oxymorphone Contraindicated
- Olanzapine / samidorphan + Oxymorphone Contraindicated
- Oxymorphone + Phenelzine Contraindicated
- Oxymorphone + Selegiline transdermal Contraindicated
Other interactions of Dantrolene
Frequently asked questions
Can I take Dantrolene with Oxymorphone?
MediHelp rates the interaction as moderate. Dantrolene and Oxymorphone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene commonly causes drowsiness, dizziness and weakness, which can add to the sedative effects of opioids. Respiratory depression is a concern, particularly in patients with limited respiratory reserve.
How serious is the interaction between Dantrolene and Oxymorphone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for oversedation and respiratory compromise, and begin with low opioid doses. Warn patients about impaired alertness.
What other medicines interact with Oxymorphone?
MediHelp also lists interactions of Oxymorphone with, for example, Alvimopan, Ethanol, Isocarboxazid. The full list is on the Oxymorphone page.
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