Drug interactions
Dantrolene + Pexidartinib
Severity: Major
Dantrolene and Pexidartinib: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both dantrolene and pexidartinib carry the risk of serious liver injury, and pexidartinib is labeled with a boxed warning for hepatotoxicity. Using them together could increase the likelihood or severity of liver damage.
What this interaction means in plain words
Dantrolene and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Dantrolene belongs to Musculoskeletal; Pexidartinib belongs to Oncology.
Why it happens
Additive hepatotoxicity from two drugs that independently injure the liver.
What to do
Avoid the combination where possible and choose an alternative to one agent. If both are essential, monitor liver enzymes and bilirubin closely and stop therapy at signs of liver injury.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Dantrolene
Other interactions of Pexidartinib
Frequently asked questions
Can I take Dantrolene with Pexidartinib?
MediHelp rates the interaction as major. Dantrolene and Pexidartinib can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Both dantrolene and pexidartinib carry the risk of serious liver injury, and pexidartinib is labeled with a boxed warning for hepatotoxicity. Using them together could increase the likelihood or severity of liver damage.
How serious is the interaction between Dantrolene and Pexidartinib?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and choose an alternative to one agent. If both are essential, monitor liver enzymes and bilirubin closely and stop therapy at signs of liver injury.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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