Drug interactions
Dantrolene + Secobarbital
Severity: Moderate
Dantrolene and Secobarbital: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Secobarbital is a barbiturate hypnotic with strong central depressant effects, and dantrolene adds drowsiness and muscle weakness. The combination can cause pronounced sedation and, at higher doses, respiratory depression.
What this interaction means in plain words
Dantrolene and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Secobarbital belongs to Central Nervous System.
Why it happens
Additive central nervous system depression.
What to do
Use the lowest effective doses and monitor sedation and respiratory function. Avoid alcohol and other central depressants.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Secobarbital
- Calcium / magnesium / potassium / sodium oxybates + Secobarbital Contraindicated
- Doravirine + Secobarbital Contraindicated
- Elbasvir / grazoprevir + Secobarbital Contraindicated
- Elvitegravir / cobicistat / emtricitabine / tenofovir df + Secobarbital Contraindicated
- Isavuconazonium + Secobarbital Contraindicated
- Lonafarnib + Secobarbital Contraindicated
Frequently asked questions
Can I take Dantrolene with Secobarbital?
MediHelp rates the interaction as moderate. Dantrolene and Secobarbital can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Secobarbital is a barbiturate hypnotic with strong central depressant effects, and dantrolene adds drowsiness and muscle weakness. The combination can cause pronounced sedation and, at higher doses, respiratory depression.
How serious is the interaction between Dantrolene and Secobarbital?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses and monitor sedation and respiratory function. Avoid alcohol and other central depressants.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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