Drug interactions
Dantrolene + Sufentanil
Severity: Moderate
Dantrolene and Sufentanil: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dantrolene can cause drowsiness and dizziness, and sufentanil is a potent opioid causing sedation and respiratory depression. Together they may increase CNS and respiratory depression.
What this interaction means in plain words
Dantrolene and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Sufentanil belongs to Musculoskeletal.
Why it happens
Additive CNS depressant effects.
What to do
Monitor sedation level and respiratory rate and titrate sufentanil to the lowest effective dose. Ensure appropriate monitoring and airway support are available when used perioperatively.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Sufentanil
- Alprazolam + Sufentanil Major
- Amitriptyline + Sufentanil Major
- Amobarbital + Sufentanil Major
- Aripiprazole + Sufentanil Major
- Asenapine + Sufentanil Major
- Baclofen + Sufentanil Major
Frequently asked questions
Can I take Dantrolene with Sufentanil?
MediHelp rates the interaction as moderate. Dantrolene and Sufentanil can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dantrolene can cause drowsiness and dizziness, and sufentanil is a potent opioid causing sedation and respiratory depression. Together they may increase CNS and respiratory depression.
How serious is the interaction between Dantrolene and Sufentanil?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor sedation level and respiratory rate and titrate sufentanil to the lowest effective dose. Ensure appropriate monitoring and airway support are available when used perioperatively.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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