Drug interactions
Dantrolene + Voxelotor
Severity: Moderate
Dantrolene and Voxelotor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Voxelotor inhibits CYP3A4 in the gut and liver and can raise exposure to sensitive substrates. Dantrolene exposure may rise, increasing sedation, weakness and liver toxicity risk, but the effect has not been well studied.
What this interaction means in plain words
Dantrolene and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Voxelotor belongs to Miscellaneous.
Why it happens
Voxelotor inhibits CYP3A4, potentially reducing dantrolene metabolism.
What to do
Monitor liver function tests and for excess sedation or weakness, and consider lowering the dantrolene dose if these occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Voxelotor
- Amobarbital + Voxelotor Major
- Apalutamide + Voxelotor Major
- Carbamazepine + Voxelotor Major
- Cyclosporin + Voxelotor Major
- Efavirenz + Voxelotor Major
- Enzalutamide + Voxelotor Major
Frequently asked questions
Can I take Dantrolene with Voxelotor?
MediHelp rates the interaction as moderate. Dantrolene and Voxelotor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Voxelotor inhibits CYP3A4 in the gut and liver and can raise exposure to sensitive substrates. Dantrolene exposure may rise, increasing sedation, weakness and liver toxicity risk, but the effect has not been well studied.
How serious is the interaction between Dantrolene and Voxelotor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor liver function tests and for excess sedation or weakness, and consider lowering the dantrolene dose if these occur.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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