Drug interactions
Dantrolene + Ziprasidone
Severity: Moderate
Dantrolene and Ziprasidone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs may cause somnolence, so combined use can increase sedation and reduce alertness. Ziprasidone's QT effect is unrelated to dantrolene.
What this interaction means in plain words
Dantrolene and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Dantrolene belongs to Musculoskeletal; Ziprasidone belongs to Central Nervous System.
Why it happens
Additive central nervous system depressant effects.
What to do
Monitor for excess sedation and counsel on driving and machinery. Adjust doses if drowsiness is troublesome.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dantrolene
Other interactions of Ziprasidone
- Amiodarone + Ziprasidone Contraindicated
- Amitriptyline + Ziprasidone Contraindicated
- Arsenic trioxide + Ziprasidone Contraindicated
- Bedaquiline + Ziprasidone Contraindicated
- Chloroquine + Ziprasidone Contraindicated
- Citalopram + Ziprasidone Contraindicated
Frequently asked questions
Can I take Dantrolene with Ziprasidone?
MediHelp rates the interaction as moderate. Dantrolene and Ziprasidone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Both drugs may cause somnolence, so combined use can increase sedation and reduce alertness. Ziprasidone's QT effect is unrelated to dantrolene.
How serious is the interaction between Dantrolene and Ziprasidone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for excess sedation and counsel on driving and machinery. Adjust doses if drowsiness is troublesome.
What other medicines interact with Dantrolene?
MediHelp also lists interactions of Dantrolene with, for example, Benzhydrocodone / acetaminophen, Buprenorphine long-acting, Buprenorphine subdermal implant. The full list is on the Dantrolene page.
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